Hemodialysis does not alter serum half-life.ĭoxycycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. Studies have shown no significant difference in serum half-life of doxycycline (range 18-22 hours) in individuals with normal and severely impaired renal function. This percentage excretion may fall as low as 1-5%/72 hours in individuals with severe renal insufficiency (creatinine clearance below 10 mL/min). Time of Maximum Concentration 2.60 hr (± 1.10 sd)Įlimination Rate Constant 0.049 per hr (± 0.030 sd)Įxcretion of doxycycline by the kidney is about 40%/72 hours in individuals with normal function (creatinine clearance about 75 mL/min). Maximum Concentration 3.61 μg/mL (± 0.9 sd) Doxycycline is virtually completely absorbed after oral administration.įollowing a 200 mg dose of doxycycline monohydrate, 24 normal adult volunteers averaged the following serum concentration values: They are concentrated by the liver in the bile and excreted in the urine and feces at high concentrations in a biologically active form. Tetracyclines are readily absorbed and are bound to plasma proteins in varying degrees. The capsules are printed with edible ink containing black iron oxide, red iron oxide, and yellow iron oxide for the 50 mg and 100 mg strengths and black iron oxide, FD&C Blue No. Inert ingredients: colloidal silicon dioxide magnesium stearate microcrystalline cellulose sodium starch glycolate and a hard gelatin capsule which contains black iron oxide, red iron oxide, titanium dioxide, and yellow iron oxide for the 100 mg and 75 mg strengths, titanium dioxide and yellow iron oxide for the 50 mg strength. Doxycycline will not degrade into an epianhydro form. It is highly stable in normal human serum. The chemical designation of the light-yellow crystalline powder is alpha-6-deoxy-5-oxytetracycline.ĭoxycycline has a high degree of lipid solubility and a low affinity for calcium binding. Doxycycline monohydrate capsules 100 mg, 75 mg, and 50 mg capsules contain doxycycline monohydrate equivalent to 100 mg, 75 mg, or 50 mg of doxycycline for oral administration. Doxycycline is a broad-spectrum antibacterial synthetically derived from oxytetracycline.
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